Papaverine and hepatotoxicity.

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Papaverine and hepatotoxicity.

Six of 14 patients receiving a sustained release papaverine preparation developed abnormal liver function tests. One patient had jaundice and another abnormal liver histology on a biopsy specimen. This is only the third report of impaired liver function following the administration of papaverine--a drug which has been used in clinical medicine for over 100 years.

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Five cases of ipsilateral pupillary dilatation that developed during local intraarterial infusion of papaverine are reported. All patients were being treated for symptomatic vasospasm secondary to subarachnoid hemorrhage. In each case, the tip of the infusion catheter was positioned in the internal carotid artery in close proximity to the ostium of the ophthalmic artery. Pupillary dilatation in...

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Photostabilization of papaverine hydrochloride solutions.

Abstract: The stability of aqueous and non-aqueous papaverine hydrochloride solutions exposed to the UV radiation is poor. In order to enhance its photo-stability suitable light absorbers may be used. There werefour photo-protectors considered in this work: 4-aminobenzoic acid, sodium benzoate, methyl 4-hydroxybenzoate and propyl 4-hydroxybenzoate, whose UV absorption spectra characteristics ma...

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Infusing doubt into the efficacy of papaverine.

Fujiwara et al (11). Morphologic changes noted Since the first report, in 1984 by Zubkov (1), of the use of intracranial balloon angioplasty for subarachnoid hemorrhage–induced cerebral vasospasm, endovascular techniques have gained acceptance as valuable therapies in the treatment of vasospasm resistant to conventional therapies (2–6). Although angioplasty and intraarterial papaverine infusion...

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Effects of Papaverine upon Ectopic Ventricular

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ژورنال

عنوان ژورنال: Postgraduate Medical Journal

سال: 1980

ISSN: 0032-5473

DOI: 10.1136/pgmj.56.657.488